With or Without Muse

One of my muses has always been music, particularly the band U2. As I am reading the book "U2 by U2" now, I am finding comfort in so many similarities related to the creative urge and the creative struggle.

I find this passage from Bono particularly interesting:
"The lyric [to "With or Without You"] is pure torment. One of the things that was happening at the time was the collision in my own mind between being faithful to your art or being faithful to your lover. What if the two are at odds? Your gift versus domestic responsibility?...I was at least two people: the person who is responsible , protective and loyal and the vagrant and idler who just wants to run from responsibility. I thought these tensions were going to destroy me but actually, in truth, it is me. That tension, it turns out, is what makes me as an artist. Right in the centre of the contradiction, that's the place to be...
"...If I had cut loose, what would have become of me?...All of the people whom I looked up to as writers, they'd all done the same. Nothing had stood in the way, they had acted with abandon, and had lost marriages, bands, friendships, all in pursuit of the muse. But the muse is taciturn and can abandon you, leave you with nothing. My muse makes different demands...
"So that song ["With or Without You"] is about torment, sexual but also psychological, about how repressing desires makes them stronger. The most important line is probably 'And you give yourself away.'"

Do you relate to the pull between domesticity and wild abandon? How do you manage that tension?
If you are an artist, has the Muse's need for wanderlust taken you to places you would rather not have gone? Was it worth it?